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     鐮旂┒闄㈠垱鏂版€ц嵂鐗╂棭鏈熸垚鑽€ц瘎浠蜂紒涓氶噸鐐瑰疄楠屽鏄互“鍒涙柊鑽墿鐮斿彂鏃╂湡璇勪环鍜岃浆鍖栧尰瀛︽柊鎶€鏈柊浣撶郴寤虹珛涓虹洰鐨?rdquo;鐨勫垱鏂板瀷浼佷笟閲嶇偣瀹為獙瀹わ紝鐢卞ぉ娲ュ競绉戝鎶€鏈鍛樹細璁ゅ畾銆傜珛瓒冲浗闄呭墠娌匡紝瀹為獙瀹ゆ瀯寤轰簡鍩轰簬鑽墿鏃╂湡鎴愯嵂鎬ц瘎浠锋妧鏈綋绯诲拰鍒涙柊鐮旂┒鏂规硶锛岀Н鏋佸煿鍏诲垱鏂版€т汉鎵嶏紝2020骞村害澶氫汉鍏ラ€夊浗瀹剁骇闈掑勾浜烘墠銆佸ぉ娲ュ競鍜屾花娴锋柊鍖虹鎶€浜烘墠锛屾瀯寤哄垱鏂板钩鍙帮紝淇冭繘浜у鐮旂粨鍚堬紝鎺ㄥ姩鍒涙柊鑽墿鐨勭爺鍙戙€侟/div>
     1.鎴戦櫌鍒涙柊鑽墿ACT001杩涘叆鍥介檯II鏈熶复搴婅瘯楠岋紝鏂伴€傚簲鐥囪嵂鐞嗙爺绌惰閫変负銆婁腑鍥借嵂鐞嗗閫氭姤銆嬪皝闈㈡枃绔狅細ACT001鎶楄偤绾ょ淮鍖栫殑鑽悊浣滅敤鐮旂┒銆侟/div>
     ACT001鏄ぉ娲ュ浗闄呯敓鐗╁尰鑽仈鍚堢爺绌堕櫌涓庡皻寰疯嵂缂樼鎶€鑲′唤鏈夐檺鍏徃鍚堜綔寮€鍙戠殑鍘熺爺鏂拌嵂锛屾槸鍏锋湁瀹屽叏鑷富鐭ヨ瘑浜ф潈锛屽師鏂欏埗澶囥€佽嵂鐗╁紑鍙戝叿鏈夊畬鍏ㄨ嚜涓荤煡璇嗕骇鏉冿紝鍘熸枡鍒跺銆佽嵂鐗╁紑鍙戝叿鏈夊浗闄呴鍏堟€х殑鏂拌嵂銆傚崡寮€澶у涓庣爺绌堕櫌鍙岃仒闄堟偊鏁欐巿鏄鑽殑棣栧垱绉戝瀹讹紝甯﹂鍥㈤槦鐮斿彂浜?0浣欏勾锛屽凡鍦ㄨ剳鑳惰川鐦ゃ€佽偤绾ょ淮鍖栫瓑澶氫釜閫傚簲鐥囪幏寰楀崄浣欎釜鍥藉鐨勪笓鍒╀繚鎶わ紝骞惰繘鍏ュ浗鍐呭拰鍥介檯澶氫腑蹇冧复搴婅瘯楠岄樁娈点€傝繎鏃ワ紝鎴愯嵂鎬ч噸鐐瑰疄楠屽鐨勫洟闃熸姤閬撲簡ACT001鍏锋湁鎶楄偤绾ょ淮鍖栫殑鑽悊浣滅敤锛屽苟杩涜浜嗙郴缁熺爺绌讹紝鑾峰緱浜嗕腑鍥姐€佺編鍥姐€佹境娲茬瓑澶氫釜鍥藉鐨勫彂鏄庝笓鍒┿€侟br />      鏂囩珷閾炬帴锛欬br />      http://dx.doi.org/10.3969/j.issn.1001-1978.2020.12.008

     2.鎴戦櫌鍒涙柊鑽墿CP0119杞鍗庢鼎鍖昏嵂闆嗗洟锛岀浉鍏虫枃绔犲彂琛ㄤ簬Cell鍑虹増闆嗗洟鏈熷垔iScience锛圛F锛?.447锛夛細鍘荤硸鍩哄寲AZM锛圕P0119锛夐澏鍚慣ransgelin鏀瑰杽鍔熻兘鎬ц偁锠曞姩涔忓姏銆侟/div>

     鐮旂┒闄笌鍗楀紑澶у鑽闄€佸ぉ娲ュ尰绉戝ぇ瀛︽€诲尰闄㈠悎浣滐紝鍙戠幇鍘荤硸鍩哄寲AZM锛圕P0119锛夊彲鏈夋晥鏀瑰杽鍔熻兘鎬ц偁锠曞姩涔忓姏锛岃嵂鐞嗗鐮旂┒琛ㄦ槑CP0119鑳戒笌Transgelin缁撳悎锛屽苟閫氳繃淇冭繘鑲屽姩铔嬬櫧缁嗕笣缁勮鎴愮揣瀵嗙殑鏉熷拰搴斿姏绾ょ淮锛屽寮轰簡鑲犲钩婊戣倢缁嗚優鐨勬敹缂╁姏銆侰P0119鍙兘鎴愪负娌荤枟鎱紶杈撲究绉樼殑娼滃湪鑽墿锛岃鎴愭灉宸茶浆璁╁崕娑﹀尰鑽熀鍥€侟/div>
     鏂囩珷閾炬帴锛欬br />      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479357/pdf/main.pdf

     3.鍙戠幇涓嵂鍗曚綋鐧芥潹绱犳姉鑲跨槫鏂颁綔鐢紝鏂囩珷鍙戣〃浜嶵heranostics锛圛F锛?.579锛夛細COMP閫氳繃涓嶵ransgelin鐩镐簰浣滅敤淇冭繘缁撶洿鑲犵檶鐨凟MT銆侟/div>
     涓庡ぉ娲ュ尰绉戝ぇ瀛︽€诲尰闄㈢帇閭﹁寕鏁欐巿鍥㈤槦鍚堜綔锛屽彂鐜癈OMP鍦ㄩ珮鎭舵€х粨鐩磋偁鐧屼腑楂樿〃杈撅紝骞朵笌TAGLN琛ㄨ揪鍛堟鐩稿叧銆侰OMP杩囪〃杈惧彲淇冭繘缁撶洿鑲犵檶鐨凟MT銆備粠鏈ㄨ澊铦朵腑鎻愬彇鐨勯粍閰被鍖栧悎鐗╃櫧鏉ㄧ礌鑳藉鎶戝埗COMP锛屼粠鑰岄樆姝MT鍜岀粨鐩磋偁鐧岀殑鎭舵€ц繘灞曘€侟/div>
     鏂囩珷閾炬帴锛欬br />      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392026/pdf/thnov10p8790.pdf

     4.鍙戠幇鑴戣绠$梾鏂板瀷琛€娓呮爣蹇楃墿锛屾枃绔犲彂琛ㄤ簬Frontiers in Physiology锛圛F锛?.367锛夛細circAFF1閫氳繃miR-516b/SAV1/YAP1閫氳矾璋冭妭鍐呯毊缁嗚優鍔熻兘銆侟/div>
     涓庡ぉ娲ュ競鐜箹鍖婚櫌鍏卞悓鍚堜綔鐮旂┒鍙戠幇锛宑ircAFF1閫氳繃miR-516b/SAV1/YAP1閫氳矾璋冭妭鍐呯毊缁嗚優鍔熻兘锛岃璁″揩閫熷畾閲廝CR妫€娴嬭洓缃戣啘涓嬭厰鍑鸿锛屽叿鏈夌壒寮傛€у己銆佺伒鏁忓害楂樼殑鐗圭偣锛屽叾棰勮浣滅敤鏃╀簬褰卞儚瀛︼紝涓斿湪鎬ユ€ф湡銆佸悍澶嶆湡鍛堜即闅忔€у姩鎬佸彉鍖栵紝鍏锋湁涓€瀹氱殑涓村簥璇婃柇鎰忎箟銆侟/div>
     鏂囩珷閾炬帴锛欬br />      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425207/pdf/fphys-11-00899.pdf

     5.鍙戠幇蹇冭倢姊楁鐩稿叧鍒嗗瓙鏈哄埗锛屾枃绔犲彂琛ㄤ簬Aging锛圛F锛?.831锛夛細娌夐粯circFASTKD1鍙互閫氳繃鍒烘縺浣撳琛€绠$敓鎴愶紝杩涜€屽蹇冩鍙戞尌娌荤枟浣滅敤銆侟/div>
     涓庝笁涓績鍖婚櫌鍏卞悓鍚堜綔鐮旂┒鍙戠幇锛屾矇榛榗ircFASTKD1鍙互閫氳繃鍒烘縺浣撳琛€绠$敓鎴愶紝杩涜€屽蹇冩鍙戞尌娌荤枟浣滅敤锛宑ircFASTKD1鍙兘鏄績琛€绠$柧鐥呮綔鍦ㄧ殑娌荤枟闈剁偣銆侟/div>
     鏂囩珷閾炬帴锛欬br />      https://doi.org/10.18632/aging.202305
 
     6.涓庤嚦鏈疄楠屽鍚堜綔寮€鍙戝叏鏂板姛鑳芥€ф姢鑲ゅ搧鍘熸枡锛屾枃绔犲彂琛ㄤ簬Theranostics锛圛F锛?.579锛夛細绾㈡櫙澶╄嫹鍙婂叾琛嶇敓鐗╂不鐤楃値鎬х毊鑲よ壊绱犳矇鐫€鐥囩殑鍒嗗瓙鑽悊鏈哄埗銆侟/div>
     涓庤嚦鏈疄楠屽鍚堜綔锛屽彂鐜扮孩鏅ぉ鑻锋姉PIH鐨勮嵂鐞嗕綔鐢ㄦ満鍒躲€傝鐮旂┒闃愰噴浜嗙値鐥囦粙瀵奸叒姘ㄩ吀閰惰〃杈剧殑鍒嗗瓙鏈哄埗锛屼篃鎻愮ず绾㈡櫙澶╄嫹鍙婂叾鍖栧琛嶇敓鐗╂湁鏈涙垚涓轰竴绫荤毊鑲ょ編鐧芥姢鑲ゅ搧鐨勬椿鎬ф垚鍒嗘垨鏂板瀷PIH澶囬€夋不鐤楄嵂鐗┿€侟/div>
     鏂囩珷閾炬帴锛欬br />      https://www.thno.org/v10p11110.htm
 
     7.涓庢祹瀹佷竴闄勯櫌鍚堜綔鎶ラ亾钁姦绱燘鎶楄偪鐦ゆ満鍒讹紝鏂囩珷鍙戣〃浜嶰ncogene锛圛F锛?.971锛夛細LN-5γ2涓庢暣鍚堢礌β1鐩镐簰浣滅敤锛屾縺娲籝AP閫氳矾锛屼績杩涚粨鐩磋偁鐧岃偪鐦ゅ嚭鑺姐€侟/div>
     涓庢祹瀹佸尰瀛﹂櫌闄勫睘鍖婚櫌鍒樺溅鑽f暀鎺堝洟闃熷悎浣滐紝鍙戠幇钁姦绱燘鍙互闃绘柇LN-5γ2涓庢暣鍚堢礌β1鐨勭浉浜掍綔鐢紝杩涜€屽鑷碮AP鐨勫け娲昏€屾樉钁楁姂鍒剁粨鐩磋偁鐧岀粏鑳炵殑鑲跨槫鍑鸿娊銆傝繖椤圭爺绌朵负缁撶洿鑲犵檶鍙戠梾鏈哄埗鍙婅嵂鐗╃殑鐮旂┒鎻愪緵鏂扮嚎绱€侟/div>
     鏂囩珷閾炬帴锛欬br />      https://www.nature.com/articles/s41388-019-1082-1
 
     8.涓庡崡寮€澶у鍚堜綔鎶ラ亾鏈ㄧ妧鑽夌礌鎶楄偪鐦よ嵂鐞嗘満鍒讹紝鏂囩珷鍙戣〃浜嶫OURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH锛圛F锛?.068锛夛細THOC1鎶戝埗鑲濈檶鐨勫娈栵紝骞跺鍔犺偪鐦ゅ閾傝嵂鐨勬晱鎰熸€с€侟/div>
     鐮旂┒鍙戠幇澶╃劧鍒嗗瓙鏈ㄧ妧鑽夌礌闈跺悜THOC1锛屽彲浠ラ€氳繃R-Loops澧炲姞鏉ョ牬鍧忓熀鍥犵粍绋冲畾鎬э紝鏄捐憲澧炲姞鑲跨槫缁嗚優鍐匘NA鎹熶激鐨勭Н绱紝鎶戝埗鑲跨槫缁嗚優鐨勫娈栭€熷害骞惰瀵煎ぇ閲忚偪鐦ょ粏鑳炲噵浜°€傝鐮旂┒鍒濇闃愰噴鎶戝埗THOC1/R-Loops鍏锋湁娼滃湪鐨勯澏鐐规垚鑽€э紝涓烘柊鍨嬫姉鑲跨槫鑽墿鐨勫紑鍙戞彁渚涗簡鎬濊矾锛屽悓鏃朵篃鎻愮ず浜嗘湪鐘€鑽夌礌鍙婂叾琛嶇敓鐗╃殑娼滃湪鏂拌嵂寮€鍙戜环鍊笺€侟/div>
     鏂囩珷閾炬帴锛欬/span>
     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362638/pdf/13046_2020_Article_1634.pdf

     9.寮€鍙戞不鐤楁伓鎬ц吂姘寸撼绫宠嵂鐗╋紝鏂囩珷鍙戣〃浜嶵heranostics锛圛F锛?.579锛夛細鍒跺涓€绉嶆牳澹冲姛鑳藉瀷绾崇背纭掗绮?ldquo;Selene”銆侟/div>
     鐮斿埗鐨勫姛鑳芥€х撼绫崇棰楃矑“Selene”锛屽彲鏈夋晥闈跺悜鑲跨槫缁嗚優琛ㄩ潰鐨凾LR4锛岀粡鐢卞唴绐栦綋閫斿緞閫掗€佽繘鍏ョ嚎绮掍綋锛屾姂鍒剁値鐥囧洜瀛愬垎娉屻€佽浆鍙樼粏鑳炴浜℃柟寮忥紝闃绘柇鑵规按浜х敓鐨勭梾鐞嗙敓鐞嗚繃绋嬶紝鏈夋晥鍦颁笖鎸佷箙鐨勬秷闄よ吂姘达紝鏈夋湜鎴愪负涓€绉嶆不鐤楁伓鎬ц吂姘寸殑鏂板瀷鑽墿銆侟/div>
     鏂囩珷閾炬帴锛欬br />      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415812/pdf/thnov10p9083.pdf

     10.棣栧垱闈跺悜鑲犻亾鑿岀兢鏂拌嵂HMPA娌荤枟II鍨嬬硸灏跨梾锛屾枃绔犲彂琛ㄤ簬鑽悊瀛︿唬琛ㄦ€ф湡鍒夿RITISH JOURNAL OF PHARMACOLOGY锛圛F锛?.730锛夛細娼滃湪鑽墿HMPA鍙互閫氳繃鑲犻亾寰敓鐗╃兢鍙戞尌闄嶈绯栦綔鐢ㄣ€侟/div>
     HMPA閫氳繃闈跺悜鑲犻亾鑿岃泲鐧紾lnR鎻愰珮鑲犻亾寰敓鐗╃兢瀵圭⒊鍒嗚В浠h阿鐨勬姂鍒朵綔鐢紝澧炲姞SCFAs鐨勪骇鐢燂紝鎻ず浜咷lnR鍙兘鏄偁閬撳井鐢熺墿缇よ皟鎺х殑闈舵爣銆傝鏂囩珷鎻愬嚭浜嗗皬鍒嗗瓙鑽墿鍙互浠呬綔鐢ㄤ簬鑲犻亾鑿岀兢鍗冲彲娌荤枟浜轰綋鏈哄埗鐨勫叏鏂拌嵂鐞嗘満鍒跺拰鑽墿寮€鍙戞€濊矾銆侟/div>
     鏂囩珷閾炬帴锛欬br />      https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15338

     11.鍙戠幇鐢樿崏閰告姉鑲濈檶鑽悊浣滅敤锛屾枃绔犲彂琛ㄤ簬Frontiers in Oncology(IF:4.848)锛氱敇鑽夐吀鑳藉闈跺悜JNK1璇卞鑲濈檶鍒嗗寲骞跺寮洪搨鑽殑鐤楁晥銆侟/div>
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     鏂囩珷閾炬帴锛欬br />      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962306/

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     鏂囩珷閾炬帴锛欬br />      https://doi.org/10.1007/s10456-020-09744-8


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